Genova Metabolomix+ is a urine based specialty test developed by Genova Diagnostics that evaluates metabolic function, nutritional status, and biochemical pathway activity. The assessment measures a broad panel of organic acid biomarkers using mass spectrometry based analytical technology and may provide insight into mitochondrial function, energy production, amino acid metabolism, fatty acid metabolism, neurotransmitter metabolism, oxidative stress, detoxification pathways, gut microbial metabolites, and nutrient cofactor status. (Lin 2024)
By evaluating patterns of urinary metabolites, Genova Metabolomix+ may support the assessment of functional metabolic imbalances that can contribute to complex or persistent clinical presentations. Providers may consider the test when evaluating suspected nutrient insufficiencies, altered energy metabolism, gastrointestinal health, oxidative stress, or metabolic pathway dysfunction as part of a comprehensive clinical workup. (Dalamaga 2024) Test results should be interpreted alongside the patient's history, physical examination, and other laboratory findings, because metabolite patterns may suggest areas for further evaluation but are not diagnostic on their own.
Quick Facts
- Laboratory: Genova Diagnostics
- Specimen: First-morning void urine. Optional dried blood spot and buccal swab add-ons are available when ordered.
- Technology: Organic acids are analyzed using GC-MS and related laboratory methodologies. Additional biomarkers, nutrient markers, toxic elements, amino acids, and optional add-on analyses are incorporated into the integrated Metabolomix+ report.
- Turnaround Time: Approximately 14 business days
- Collection Method: At-home collection kit (first-morning urine); optional bloodspot finger stick and buccal swab when those add-ons are ordered
- Availability: Provider-ordered — only licensed healthcare providers may order. Genova lists Metabolomix+ as not available in New York and not available for patients under 2 years of age.
